Ryan Stiles has starred in all three incarnations of Whose Line—the British version (1989-98); the American version hosted by Drew Carey (1998-2006); and the current version hosted by Aisha Tyler. He also executive produced both American versions.

In addition, Stiles also portrayed Lewis, the luckless janitor, on the hit sit-com The Drew Carey Show and recurred for several seasons as Dr. Herb Melnick on the popular series Two and a Half Men. His film work includes Hot Shots, Hot Shots, Part Deux, and the Academy Award-nominated short film Rainbow War. He recently produced a feature-length documentary called Out of Nothing, about four men competing to break the motorcycle land-speed record on the salt flats of Bonneville.