Founded by Jorge Glem, Edward Ramírez, and Héctor Molina in 2005, C4 Trío has as main protagonist the Cuatro Venezolano. As one of the most important and innovative Venezuelan musical proposals characterized by an unusual format, C4 Trío mixes elements of traditional music, jazz, pop, world music, and Latin music. In 2009, Rodner Padilla (electric bass) joins the ensemble.
C4 Trío has toured in America and Europe and recorded 6 albums with great sale success. In 2013, Gualberto + C4 obtained a nomination to the Latin Grammy as Best Folk Album. One year later, the album De Repente, made in collaboration with the singer Rafael "Pollo" Brito, obtains the Latin Grammy as "Best Recording Engineering for an Album".
In 2015, they produced Los10DeC4, a DVD commemorating their 10 years, directed by Hernán Jabes, with the participation of some of the most outstanding Venezuelan artists.
In 2018 his album Pa Fuera, made in collaboration with the Ska band "Desorden Público", was nominated for the 60th Grammy Award as "Best latin, rock and alternative album" and in 2019 the album Tiempo al tiempo, made in collaboration with the singer Luis Enrique, obtains the Latin Grammy as “Best Folk Album” and a nomination to the 62nd Grammy Awards as “Best Tropical Latin Album”.
C4 Trío since its foundation has an intense concert agenda in the most important stages of America and Europe, showing the versatility and universality of the Venezuelan Cuatro.