Ramona Gonzalez began as Nite Jewel in 2008 as the result of her juggling music with undergraduate studies. She cites artists such as Janet Jackson and Mariah Carey as her musical inspirations. With assistance from her husband, Cole M.G.N., she created songs on a portable eight-track cassette recorder. She stated that "moments of ecstasy, emotion, and hardship" were her inspiration for those recordings. In 2009 she released the album Good Evening.

Soon after starting her MySpace music page, her song, "Suburbia" was selected to be in Noah Baumbach's film Greenberg. Within a year she was touring European festivals. Her music draws comparison to Lisa Lisa and Cult Jam. Nite Jewel describes herself more as "liquid cool" citing English electronic music duo Autechre as a major musical influence. Ramona Gonzalez has a bachelor's degree in philosophy from Occidental College. She is also a multimedia artist and has exhibited a number of video and sound installation pieces in the L.A area, one of which was entitled The Question Concerning Technology.

On December 6, 2011, Nite Jewel released her single, "She's Always Watching You". On March 6, 2012, Ramona released her second album One Second of Love, on Secretly Canadian. The company reissued the first album, Good Evening, on vinyl in 2012. Since releasing her debut album for Secretly Canadian, Nite Jewel has toured both North America and Europe. She performed Kraftwerk's Computer World in Los Angeles' Krautrock Classics on June 1, 2012. Later that summer, she traveled to New York City to perform in the same event at Le Poisson Rouge. Gonzalez left Secretly Canadian and recorded her third album, Liquid Cool, which was released in June 2016 on her own label, Gloriette.

Real High, which is Ramona Gonzalez's fourth full-length, is due out May 5, 2017. The album is inspired by the ups and downs—particularly the euphoric highs—of love, nodding to the "hopefully naive" spirit of Janet Jackson's classic 1993 record, janet. "Gonzalez updates this feminine inner dialogue to reflect the increasing challenges of hyper-modern society," the label says, "in particular with respect to selfhood." It was made over four years in LA and features collaborations with Julia Holter, Droop-E and Dâm-Funk, who she recently released an EP with as Nite-Funk.